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What is Lithium Used For?
Lithium is a state of mind stabilizer and can help to treat or stop mania. It can additionally be used to reduce the frequency of clinical depression episodes.
Take this medicine as directed by your physician. It is important to consume a lot of fluids while taking this medicine. Lithium might interact with certain medications that influence serotonin (such as antidepressants, SSRIs, MAO inhibitors). Inform your medical professional regarding every one of your medications.
Mood Problems
Lithium is frequently utilized to deal with bipolar disorder, a mental disorder that creates very fast shifts in between the severe state of minds of depression and mania. Bipolar affective disorder can make it difficult to live a regular life and can cause major troubles in relationships, work or college. Lithium helps to prevent these severe state of mind adjustments and decreases the seriousness of anxiety and mania.
The very early researches of lithium at Glostrup Psychiatric Hospital in the 1960s and 1970s provided convincing evidence that it can decrease the regularity of hospital stays for clinical depression (38 ). Baastrup and Schou's placebo-controlled discontinuance research was specifically vital because it showed that clients fell back on sugar pill yet out lithium (39 ).
Your medical professional will check your blood levels routinely to make certain you are taking the proper quantity of lithium. It is important to consume a lot of liquids while taking this medication. Your doctor might recommend a low-sodium diet regimen while you are taking this medication.
Attention Deficit Hyperactivity Disorder (ADHD).
Lithium is a mineral so soft you can suffice with a knife therefore light it floats on water. It is located naturally in the setting, with research studies linking reduced levels of it to emotional and psychological health problems and terrible criminal offense. The mineral was added to sodas in the 1960s, where it brightened state of minds and helped individuals focus and focus-- hence the name, 7-Up.
Lithium minimizes mania by increasing the activity of an enzyme that regulates natural chemicals, decreasing glutamate levels, and helping to stabilize various other chemicals in the mind. It has actually additionally been shown to have antidepressant results and improve rest, irritability, hostility, and anxiousness in ADHD clients.
Individuals taking lithium should have normal blood tests to keep an eye on levels-- too expensive can be toxic. It is necessary to let physicians know about various other drugs and supplements taken, as some can communicate with it. Inform your medical professional if you have diarrhea, vomiting, sleepiness, shakes, weakness, unsteady strolling, or fainting (specifically after exercise). Use reliable birth control to prevent maternity while taking this medicine.
Hyperthyroidism.
Lithium may be used as a short-term therapy for overactive thyroid glands (hyperthyroidism). This is especially vital if the individual has Graves condition or various other autoimmune problems like thyroiditis or Hashimoto's condition. Lithium hinders the launch of thyroid hormonal agent by blocking iodine uptake at the thyroid gland through the sodium-iodide symporter and by disrupting tyrosine iodination. [9] Lithium also hinders thyrotropin-releasing hormone (TRH) stimulation and decreases the production of thyroxine from tyrosine in the thyroid gland. [10] Nonetheless, lithium use may cause hypothyroidism and a goiter in some individuals. [11] Therefore, frequent assessment of thyroid feature examinations and dimension is advised in patients on lithium therapy.
It is very important to go over the advantages and threats of this medication with your physician before beginning it. It is additionally important to avoid products low in sodium (salt) while taking this medicine and beverage enough liquids. If you have any problems, call your physician or the emergency situation department right away.
Epilepsy.
The anticonvulsant results of lithium are well developed from both medical and speculative research studies. It is necessary to keep in mind that as opposed to a couple of primitive clinical records and the lithium-pilocarpine animal model, a number of recent research studies show that lithium in therapeutic levels does not lower the seizure affordable mental health treatment options limit yet in fact decreases the limit for seizure occurrence.
This is thought to result from the reality that lithium increases cholinergic task, hinders phosphoinositide metabolic rate and GSK-3b signalling. It likewise lowers glutamate excitotoxicity by increasing NMDA receptor agonist-evoked apoptotic currents and improves the endogenous nitric oxide synthase task in neurons [36]
Lithium is well endured by many people with bipolar affective disorder, yet it has a couple of negative effects that should be considered. These consist of a lowered capability to concentrate urine (nephrogenic diabetes insipidus) and a rise in the focus of lithium in the blood (lithium toxicity). It is for that reason very vital to follow your medical professional's guidelines regarding having regular blood tests.